Terry Virts has been taking photos of all 28 cities with a Major League Baseball stadium and posting them on his Twitter and Instagram accounts.
His challenge is to get baseball lovers to look at the pictures and guess the cities.
Some of the locations are being presented in groups of four with fans having to guess which is theirs.
A NASA spokeswoman says Blue Jays fans should get their chance on Wednesday.
Four pictures will be posted and fans will have to guess which one is of Toronto.
They can follow along and take a guess at all the cities using the hashtag #ISSPlayBall.
